解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Oral squamous cell carcinoma (OSCC) is a lethal malignancy and its prognosis remains dismal. Thus, a deeper understanding of the mechanisms is needed to provide a new insight for new therapies. It has been reported that long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) was downregulated in OSCC tissues, h...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2012
更新日期:2019-07-01 00:00:00
abstract::Researchers have started focusing on investigating the anticarcinogenic effects of natural products with the slightest side effects possible, because current breast cancer treatment approaches are unable to achieve absolute success especially on aggressive subtypes. Propolis is among these products with its antimicrob...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1996
更新日期:2019-05-01 00:00:00
abstract::The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown t...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1978
更新日期:2019-04-01 00:00:00
abstract::Although vitamin E has been recognized as a critical micronutrient to neuronal health for more than half a century, vitamin E transport and regulation in the brain remain a mystery. Currently, the majority of what is known about vitamin E transport has been delineated in the liver. However, clues from the pathogenesis...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1993
更新日期:2019-04-01 00:00:00
abstract::Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both antiviral and antitumor activities. Here, we have demonstrated the ability of tilorone to activate NK cells and specific subpopulations of cytotoxic CD4+ and CD8+ T lymphocytes that recog...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1985
更新日期:2019-03-01 00:00:00
abstract::Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1972
更新日期:2019-03-01 00:00:00
abstract::Extracellular matrix (ECM)-independent survival is an essential prerequisite for tumor metastasis, and a hallmark of epithelial cancer stem cells and epithelial-mesenchymal transition (EMT). Here, we found that loss of TP53I11 enhanced, and overexpression of TP53I11 suppressed the ECM-independent survival, EMT, and mi...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1949
更新日期:2019-02-01 00:00:00
abstract::The mitochondrial ATP-Mg/Pi carrier is responsible for the calcium-dependent regulation of adenosine nucleotide concentrations in the mitochondrial matrix, which allows mitochondria to respond to changing energy requirements of the cell. The carrier is expressed in mitochondria of fungi, plants and animals and belongs...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1931
更新日期:2018-12-01 00:00:00
abstract::Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1925
更新日期:2018-11-01 00:00:00
abstract::PlncRNA-1 has been suggested to function as an oncogenic role in prostate cancer, colorectal cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma, and gastric cancer. The expression pattern of PlncRNA-1 in retinoblastoma remained unknown. Therefore, the aim of this study was to explore the clinical sig...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1886
更新日期:2018-10-01 00:00:00
abstract::The complex life cycle of intracellular parasitic protozoans entails multiple rounds of DNA replication and mitosis followed by cytokinesis to release daughter parasites. To gain insights into mitotic events it is imperative to identify the biomarkers that constitute the chromosome segregation machinery in the parasit...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1878
更新日期:2018-08-01 00:00:00
abstract::Endothelial dysfunction is fundamental to ischemic stroke and brain injury. The humanin analogue S14G-humanin (HNG) has been shown to be a cytoprotective derivative. In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro. In a murine middle cerebral artery occlusion (MCAO) stroke model,...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1869
更新日期:2018-07-01 00:00:00
abstract::Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant remodelling and intimal hyperplasia (IH). MicroRNA-21 (miR-21) is a short, non-coding RNA that ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1751
更新日期:2018-07-01 00:00:00
abstract::It is known that that human serum albumin (HSA) and alpha-lactalbumin (LA) possess DNA-binding sites. Electrophoretically homogeneous HSA and LA containing no canonical enzymes were isolated from human sera and milk. Here we have analyzed for the first time the possibility of DNA hydrolysis by these proteins. It was s...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1741
更新日期:2018-06-01 00:00:00
abstract::Prostate cancer (PCa) is considered the most common malignancy in men. The aim of this study is to assess the role of serum miR-15a and miR-16-1 expression in PCa development, diagnosis and prognosis aiming to find a specific noninvasive biomarker. This study comprised 70 patients with PCa, 70 patients complaining of ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1733
更新日期:2018-05-01 00:00:00
abstract::Altered activity of the proteolytic machine-the 26S proteasome is observed in many disease conditions. Hence, either inhibition or activation of the 26S proteasome is thought to be a novel therapy for treatment of certain diseases such as cancer and neurodegenerative disorders. In this study, we tested the potential o...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1735
更新日期:2018-05-01 00:00:00
abstract::This study was expected to reveal the regulatory effects of lncRNA UCA1 on pancreatic cancer cell progression through targeting miR-96/FOXO3. Microarray analysis was carried out on 36 cases of pancreatic cancer tissues and 16 cases of adjacent tissues among them. Expression levels of lncRNA UCA1, miR-96, and FOXO3 in ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1699
更新日期:2018-04-01 00:00:00
abstract::Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver diseases. In our previous study, we reported that at concentrations above the minimal inhibitory concentration (MIC), silymarin exhibited antifungal activity against Candida albicans by targeting its plasma ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1716
更新日期:2018-03-01 00:00:00
abstract::Arginine biosynthesis pathway is crucial to the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). Arginine is a critical amino acid that contributes to the inflection of cellular immune responses during pathogenesis. Argininosuccinate lyase from Mtb (MtArgH), the last enzyme in the pathway, catalyzes the ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1683
更新日期:2017-11-01 00:00:00
abstract::Elevated homocysteine levels are known to be a risk factor for congenital cardiac septal defects (CCSDs), but the mechanism underlying this effect is unknown. The genetic variants that were significantly associated with circulating homocysteine concentrations have been systematically identified through the genome-wide...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1651
更新日期:2017-09-01 00:00:00
abstract::Specific RNAs can function as sinks for endogenous miRNAs, known as competing endogenous RNAs (ceRNAs). Here, we confirm a miR-124 mediated ceRNA crosstalk between LAMC1 and CD151 in hepatocellular carcinoma (HCC). miR-124 negatively regulates LAMC1 expression through two miRNA binding sites within its 3' untranslated...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1642
更新日期:2017-08-01 00:00:00
abstract::Hepatocyte mitochondrial aquaporin-8 (mtAQP8) works as a multifunctional membrane channel protein that facilitates the uptake of ammonia for its detoxification to urea as well as the mitochondrial release of hydrogen peroxide. Since early oligonucleotide microarray studies in liver of cholesterol-fed mice showed an AQ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1615
更新日期:2017-05-01 00:00:00
abstract::Copper has a wide and important role in biological systems, determining conformation and activity of many metalloproteins and enzymes, such as cytochrome oxidase and superoxide dismutase . Furthermore, due to its possible reactivity with nonspecific proteins and toxic effects, elaborate systems of absorption, concentr...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1590
更新日期:2017-04-01 00:00:00
abstract::Traumatic optic neuropathy is an important cause of severe vision loss. So, many attempts were performed to transplant stem cells systemically or locally to regenerate the injured retina. In this study, we investigated the effect of human umbilical cord blood mesenchymal stem cells (hUBMSCs) on histological structure,...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1608
更新日期:2017-03-01 00:00:00
abstract::Nur77 is a member of nuclear receptor superfamily that acts as a transcription factor and regulates expression of multiple genes. Subcellular localization of Nur77 protein plays an important role in the survival and cell death. In this study, we have predicted and confirmed alternatively spliced two new transcripts of...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1605
更新日期:2017-02-01 00:00:00
abstract::5-Hydroxytryptamine 2C (5-HT2C ) receptor agonists have been suggested to possess an antipsychotic activity in several acute preclinical tests of antipsychotic drugs with low extra-pyramidal side effect liability. However, little is known about the long-term effect associated with chronic use of 5-HT2C receptor agonis...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1580
更新日期:2016-12-01 00:00:00
abstract::Methionine (Met) is a neutral, sulfur-containing, essential amino acid with biological functions in the initiation and prolongation step of protein synthesis, transmethylation reactions, the synthesis of cysteine and cystine, and as a component of antioxidant systems. Its key importance is reflected by the fact that i...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1571
更新日期:2016-12-01 00:00:00
abstract::Uncoupling proteins (UCPs) mediate inducible proton conductance in the mitochondrial inner membrane. Herein, we summarize our knowledge regarding UCPs in invertebrates. Since 2001, the presence of UCPs has been demonstrated in nematodes, mollusks, amphioxi, and insects. We discuss the following important issues concer...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1535
更新日期:2016-09-01 00:00:00
abstract::Cartilage engineering is one challenging issue in regenerative medicine. Low oxygen tension or hypoxia inducible factor-1 (HIF-1α) gene therapy are promising strategies in the field of cartilage repair. Previously, we showed that hypoxia and its mediator HIF-1 regulate matrix genes expression (collagens and aggrecan)....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1539
更新日期:2016-09-01 00:00:00
abstract::1,25-Dihydroxyvitamin D3 [1,25(OH)2 D3 ] has recently been shown to have immunomodulatory property. This study aimed to investigate the expression and potential role of 1,25(OH)2 D3 in the pathogenesis of diabetic retinopathy (DR) in the Uygur population. Blood samples were obtained from 22 patients with proliferative...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1501
更新日期:2016-06-01 00:00:00
abstract::Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine in DNA. However, the role of TET enzymes in human gastric cancer remains unknown. Here, we show that TET2 mRNA and protein levels are downregulated in human gastric cancer tissues when compared with normal gastric mucosa....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1490
更新日期:2016-05-01 00:00:00
abstract::Besides its classical mode of action through activation of specific receptors at the cell surface, fibroblast growth factor 1 (FGF1) can also cross the cellular membrane and translocate into the cytosol and further to the nucleus. The mechanism of this translocation is described partially, but the role of FGF1 inside ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1480
更新日期:2016-03-01 00:00:00
abstract::The direct relationship between obesity and breast cancer has been elucidated recently with the identification of a cholesterol derivative 27-hydroxycholesterol (27HC), an endogenous SERM that can act through estrogen receptor (ER)-mediated mechanisms. Our recent research shed light on the possible SERM-like property ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1465
更新日期:2016-02-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders; however, its pathophysiology is still unclear. Certain polymorphisms of luteinizing hormone beta-subunit (LHβ) and LH/choriogonadotrophin receptor (LHCGR) genes may lead to changes in the bioactivity of this hormone. We aimed to ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1457
更新日期:2016-01-01 00:00:00
abstract::Heat shock proteins (Hsps) are a highly conserved family of proteins. The regulation of expression of Hsps in Mycobacterium tuberculosis, is regulated both positively and negatively by alternate sigma factors and transcriptional DNA repressors, respectively. HspR is a negative regulator of expression of hsps, DnaK, Cl...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1438
更新日期:2015-11-01 00:00:00
abstract::Cancer related inflammation (CRI) is now recognized as the seventh hallmark in the pathogenesis of many types of malignancies. Paeonol, a natural phenolic component isolated from the root bark of Paeonia moutan, has significant anti-inflammatory activity. Recently, accumulating body of research has revealed potent ant...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1435
更新日期:2015-10-01 00:00:00
abstract::Matrix metalloproteinase-9 (MMP-9) regulates remodeling of the left ventricle after myocardial infarction (MI) and is tightly linked to the inflammatory response. The inflammatory response serves to recruit leukocytes as part of the wound healing reaction to the MI injury, and infiltrated leukocytes produce cytokines ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1408
更新日期:2015-08-01 00:00:00
abstract::Pilins or fimbrilins are a class of proteins found in bacterial surface pilus, a hair-like surface appendage. Both the Gram-negative and -positive bacteria produce pilins to assemble pili on their cell-surface for different purposes including adherence, twitching motility, conjugation, immunomodulation, biofilm format...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1400
更新日期:2015-07-01 00:00:00
abstract::Carbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concent...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1388
更新日期:2015-06-01 00:00:00
abstract::Crude brazilin extract from Sappan wood has demonstrated strong anti tumor activity in the mouse model of human bladder carcinoma and clinical trial for intravesical therapy. Purified brazilin was confirmed the most active molecule in inhibition of bladder carcinoma T24 cells. Brazilin decreased proliferation and viab...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1357
更新日期:2015-03-01 00:00:00